Cephalosporin Drugs Market
Market Overview:
• The major factors for cephalosporin drug market growth include increased demand for anti-microbials in various indications, increased infectious disease prevalence and increased use of combination therapies.
• After bringing them through the early stage of clinical development, most tiny businesses out-license the products. In relation to the milestone payments on completion of specified developmental stage and royalties on sales, these contracts generally include one-time payment for acquiring the rights. Over the previous five centuries, there are over 50 cephalosporin drugs authorized, and nearly half of them are for antibacterial activity. However, new cephalosporins classified as the fifth generation, which are used to treat severe gram-negative bacterial infections, including methicillin-resistant Staphylococcus aureus MRSA , have recently been approved.
• Manufacturers are engaged in developing new anti-microbial resistance medicines. Resistance mechanisms have described the complexity and variety of the need for new and enhanced ?-lactam antibiotics. Additionally, the companies are involved in the strategic development of new products, for example, in 2017, Shionogi & Co. Ltd collaborated with the F. Hoffmann-La Roche Ltd for the development and commercialization of baloxavir marboxi.
• As a result, the cephalosporin drugs market is expected to witness high growth over the forecast period due to the above-mentioned factors.
Scope of the Report:
According to the scope of this report, cephalosporins form part of the group of beta-lactams and work by interfering with the bacterial cell wall synthesis. Some may be administered orally, but most are injected. Typically they are the second choice of antibiotics, their primary uses are in therapy with pneumonia, septicemia, meningitis, sinusitis and UTIs. Despite their second-line use, cephalosporins have a wider activity spectrum and are more powerful than penicillin.
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Key Trends in the Cephalosporin Drugs Market:
The Fifth-generation Segment is Expected to Account for the Largest Market Share During the Forecast Period:
In the laboratory, the cephalosporins of the fifth generation were developed to specifically target resistant bacterial strains. Ceftobiprole is particularly efficient against staphylococcus aureus MRSA resistant to methicillin. These agents, rather than cephalosporins of the fifth generation, are sometimes referred to as the advanced generation. Cephalosporins have penicillin-like side effects, as well as drug allergy and hypersensitivity. In particular, cephalosporins were correlated with low hepatotoxicity and rare drug-induced liver injury. Cephalosporins of the fifth generation are Ceftobiprole, Ceftaroline, and Ceftolozane. Ceftobiprole has strong antipseudomonal features and seems less prone to resistance growth. Ceftaroline was also defined as cephalosporin of the “fifth generation,” but does not have ceftobiprole s antipseudomonal or VRE coverage. Ceftolozane s market is increasing at a strong rate as it has opened doors to treat complex intra-abdominal infections CIAI and complex urinary tract infections CUTI . In addition, Ceftolozane is coupled with the tazobactam ?-lactamase inhibitor, as multidrug-resistant bacterial infections are usually resistant to all ?-lactam antibiotics, unless this enzyme is inhibited. Therefore, it is anticipated that the increased use of combination therapies will drive the market during the forecast period.
Asia-Pacific is Expected to be the Fastest Growing Segment in the Global Market:
Due to the high prevalence of infectious diseases, increased healthcare expenditure and a large population base, Asia-Pacific is expected to dominate this market. In addition, it is anticipated that the demand for better healthcare infrastructure and public projects will assist market growth in this region. According to the 2016 tuberculosis statistics released by the World Health Organization WHO , an estimated incidence of tuberculosis TB in India is 2.79 million instances. As a result, increasing instances of different diseases are anticipated to increase the general market growth. Europe is being followed by Asia-Pacific owing to its big geriatric population base and increasing infectious disease prevalence in several nations in the region.
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Competitive Landscape:
Due to the existence of many tiny and big market players, the market studied is fragmented. Some of the market players are Astellas Pharma Inc., Baxter International, F. Hoffmann-La Roche AG, GlaxoSmithKline PLC, Lupin Pharmaceuticals, Macleods Pharmaceuticals Ltd., Mankind Pharma, Merck & Co. Inc., Pfizer Inc., and Teva Pharmaceuticals.
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