Amifostine Ethiofos is a cytoprotective adjuvant used in cancer chemotherapy and radiotherapy involving DNA-binding chemotherapeutic agents. It is marketed by the Clinigen Group under the trade name Ethyol.
Amifostine is a pro-drug which is activated to the free thiol metabolite at the tissue site. The thiol metabolite is responsible for most of the cytoprotective and radioprotective properties of amifostine. It is readily taken up by cells where it binds to and detoxifies reactive metabolites of platinum and alkylating agents as well as scavenges free radicals. Other possible effects include inhibition of apoptosis, alteration of gene expression and modification of enzyme activity. Healthy cells are preferentially protected because amifostine and metabolites are present in healthy cells at 100-fold greater concentrations than in tumor cells.
The market is relatively concentrated and there are just a few suppliers in the market, such as Clinigen Group, Sun Pharmaceutical, Merro Pharmaceutical and so on. Clinigen Group acquired the business from AstraZeneca in the year of 2014 and signed an agreement with Cumberland in the year of 2016. Under the agreement, Cumberland acquired the exclusive rights to commercialize Ethyol in the United States. Merro Pharmaceutical owns the largest sales share in China.
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Amifostine shows good effect in reducing harmful effects of cisplatin chemotherapy on kidneys in women treated for advanced ovarian cancer as well as relieving dry mouth problems xerostomia with head and neck cancer patients undergoing radiation treatment.
The report forecasts the global Amifostine market to grow to reach $$ Million USD in 2019 with a CAGR of –% during the period 2020-2025.
Finally, the report provides a detailed profile and data information analysis of the leading Amifostine company.
Key Content of Chapters as follows including and can be customized:
- Market Overview, Development, and Segment by Type, Application & Region
- Global Market by company, Type, Application & Geography
- Asia-Pacific Market by Type, Application & Geography
- Europe Market by Type, Application & Geography
- North America Market by Type, Application & Geography
- South America Market by Type, Application & Geography
- Middle East & Africa Market by Type, Application & Geography
- Company information, Sales, Cost, Margin, etc.
- Conclusion
Market Segment as follows:
By Region
Consumption of amifostine mainly concentrates in North America. In 2016, the region consumed 780 K Unit, holding about 52% market share globally. The follower is Asia-Pacific, with about 41% consumption share.
- Asia-Pacific China, Southeast Asia, India, Japan, Korea, Oceania
- Europe Germany, UK, France, Italy, Russia, Spain, Netherlands, Turkey, Switzerland
- North America United States, Canada, Mexico
- Middle East & Africa GCC, North Africa, South Africa
- South America Brazil, Argentina, Columbia, Chile, Peru
Key Companies
- Clinigen Group
- Sun Pharmaceutical
- Taj Pharmaceuticals
- Merro Pharmaceutical
- Luye Pharma
- Mingren Pharma
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Market by Type
- 400mg/Dose
- 500mg/Dose
Market by Application
- Ovarian Cancer Adjuvant Therapy
- Head and Neck Cancer Adjuvant Therapy
- Others
Our analysts can customize this market research report to meet your requirements.
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